Chemical Reaction Networks: Filipino Contributions to Their Theory and Its Applications
Carlene P.C. Pilar-Arceo1*, Editha C. Jose2, Angelyn R. Lao3, and Eduardo R. Mendoza2,3,4,5
1Institute of Mathematics, University of the Philippines Diliman, Quezon City, Philippines
2Institute of Mathematical Sciences and Physics,
University of the Philippines Los Baños, Laguna, Philippines
3Mathematics & Statistics Department, De La Salle University, Manila, Philippines
4Physics Department, Ludwig Maximilians University, Munich, Germany
5Max Planck Institute of Biochemistry, Munich, Germany
*Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
This paper reviews the theory of chemical reaction networks and the contributions of Filipino scientists to it. The modern theory of chemical reaction networks began in the early 1970´s with the work of American chemical engineers and chemists from Canada and Russia. The field was reshaped at the turn of the century with the emergence of systems biology and biologists, computer scientists, mathematicians, and researchers from other disciplines joining the collaborative efforts. Luis F. Razon, a chemical engineer, and Baltazar D. Aguda, a chemist, were the first Filipinos to contribute to the theory with their Ph.D. theses in 1985 and 1986, respectively. Over twenty-five years later in 2014, mathematicians from several Philippine universities revived the research – focusing on power law kinetic systems and biological applications – and contributing nine international publications since. The paper concludes with a description of their current research and some promising perspectives.
In Memoriam: Baltazar D. Aguda (1956–2017)
With his Ph.D. thesis in 1986, Baltazar “Baltz” D. Aguda became one of the first two Filipinos to contribute to the theory of chemical reaction networks (CRNT for short). Through his papers on the mammalian cell cycle in 1999, Baltz became the first scientist worldwide to apply CRNT to the emerging field of systems biology.
After an absence of more than 35 years, Baltz returned to the Philippines in May 2016 to become the Executive Director of the Philippine Genome Center and a Research Professor at the University of the Philippines. In August 2017, he succumbed to lung cancer – a tragic loss for the country´s research community. We dedicate this essay to the memory of this remarkable Filipino scientist. . . . . read more
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