Minimum Inhibitory Concentrations of Aminoglycoside, b-lactam and Quinolone Antimicrobials for Nosocomial Isolates of Acinetobacter calcoaceticus-Acinetobacter baumanii Complex from the Philippine General Hospital
Eesperanza C. Cabrera*1, Roslyn DM. Rodriguez2, Patricio L. Cantiller1 and Anthony C. Lee1
1Biology Department, De La Salle University, 2401 Taft Avenue, Manila
2Bacteriology Section, Department of Laboratories,
Philippine General Hospital, Taft Avenue
Acinetobacter calcoaceticus-Acinetobacter baumanii complex isolates from patients of the Philippine General Hospital with hospital-acquired (nosocomial) infections were analyzed for their response to amikacin, gentamicin, netilmicin, tobramycin, ceftazidime, cefotaxime, piperacillin, ciprofloxacin and cefoperazone. The minimum inhibitory concentrations of the antimicrobial agents for the isolates were determined using the agar dilution method. Of the 98 isolates studied, 97 (98.98%) were resistant to at least one of the antimicrobials, with 17 of these 97 isolates (17.53%) being resistant to all of the nine tested. The aminoglycosides netilmicin and amikacin were shown to be the most effective against the isolates, with 61.22% and 56.12% being sensitive to the antimicrobials, respectively. This was followed by the b-lactam ceftazidime, to which 40.82% of the isolates were sensitive. Cefoperazone was the least effective, with 91.83% being resistant to it. The aminoglycosides were shown to be generally more effective than the b-lactam and quinolone antimicrobials.
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