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Obesity-related Single Nucleotide Polymorphisms FTO and GHSR Genes and the Postprandial Feeling of Fullness in Filipino Adults

Jacus S. Nacis*, Ma. Julia Golloso-Gubat, Vanessa Joy A. Timoteo,
Edward Vincent J. Magtibay, Mildred A. Udarbe, and Noelle Lyn C. Santos

Nutrition Research and Development Group, Food and Nutrition Research Institute,
Department of Science and Technology, Taguig City, Metro Manila 1631 Philippines

*Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

ABSTRACT

Obesity-related single nucleotide polymorphisms (SNPs) may impact the control of energy intake and eating behavior. However, the effect size of those individual SNPs is not yet fully elucidated. Intervention studies using a standardized test meal coupled with a validated visual analogue scale (VAS) is important in understanding the influence of SNPs in the subjective feeling of appetite. This study aimed to assess the influence of obesity-related SNPs on appetite responses of Filipino adults following consumption of equicaloric breakfast meals. In an intervention study, thirty-four apparently healthy Filipino adults were genotyped for SNPs in the fat mass and obesity-associated gene (FTO) and growth hormone secretagogue receptor (GHSR). A validated VAS was used to capture the pre- and post-prandial feeling of the appetite of the study participants. Analysis of covariance (ANCOVA) was used to determine the differences between the subjective ratings of appetite (hunger, fullness, desire to eat, and prospective consumption) relative to the genotype of the study participants. The mean rating of fullness was 5.6% lower in carriers of the risk-allele A for FTO rs9939609 and 16.6% higher in carriers of the risk-allele A for GHSR rs572169. The levels of fullness after a meal is significantly influenced by the obesity-related SNPs FTO rs9939609 and GHSR rs572169 after controlling for age, sex, height, weight, BMI, and baseline appetite scores of the study participants. Our result implies that genetic polymorphisms might pose control of subsequent food intake.

 

INTRODUCTION

According to the World Health Organization (WHO 2018), in 2016, a total of more than 650 million adults were obese worldwide. The worldwide obesity prevalence has gone triple since 1975 and it continues to pose serious debilitating clinical conditions (WHO 2018).  
In the Philippines, the Food and Nutrition Research Institute (DOST-FNRI) reported that in 2013, three in every 10 adults were overweight and obese. Obesity as classified by either BMI, waist circumference (WC), or waist-hip ratio (WHR) is found to be high in prevalence (DOST-FNRI 2015). As such, the problem of overweight and obesity has been one of the key issues being addressed by the Philippine Plan of Action for Nutrition 2017-2022 – along with stunting and wasting among children, deficiencies in vitamin A, iron, and iodine, hunger and . . . . . read more

 

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