Continuous Logical Modeling of the Submergence Regulatory Network in Rice
Allen L. Nazareno1*, Maribel L. Dionisio-Sese2, Genaro A. Cuaresma1,
Eduardo R. Mendoza1,3, and Editha C. Jose1
1Institute of Mathematical Sciences and Physics
University of the Philippines Los Baños, Laguna, Philippines
2Institute of Biological Sciences
University of the Philippines Los Baños, Laguna, Philippines
3Department of Membrane Biochemistry
Max Planck Institute of Biochemistry, Martinsried, Germany
*corresponding author:This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The study on the interaction of different hormones involved in plant developmental processes under environmental stresses is an important area of concern in systems biology. With this, a detailed network structure of submergence regulatory system in rice (Oryza sativa L.) was analyzed using continuous logical modeling. The model correctly simulated the functioning of core components of the network. Moreover, it showed oscillatory behavior of majority of the components, which is consistent with the notion of inherent buffering in signaling networks. A prediction of the role of SUBMERGENCE 1A (SUB1A) in sustained oscillatory behavior of ethylene during submergence in water was also established.
INTRODUCTION
Studying plant hormones has been an emerging trend in systems biology. Plant hormones or phytohormones are generally defined as low molecular mass substances, which, in very dilute concentrations and without being altered chemically, perform specific regulatory functions usually beyond the individual cell. They are responsible for plant's metabolic homeostasis and developmental stability. Specifically, they function as transportable messenger substances and as indigenous signal transmitters (Mohr & Schopfer 1995). Their mechanism of action and the underlying processes related therein have aroused the interest of a vast number of biologists, chemists and even mathematicians. . . . . read more
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