In Vitro Controlled Drug Release of Anticancer Drugs
Deguelin and Cisplatin by Lauric Acid
Derived Polyanhydride as Carrier
John Marty Mateo1 and Florentino C. Sumera*
1Natural Sciences Research Institute, University of the Philippines,
Diliman, Quezon City, 1101, Philippines
*Institute of Chemistry, University of the Philippines,
Diliman, Quezon City,1101, Philippines
*Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
New lauric acid derived polyanhydride was used in wafer form as carrier in the study of drug release of two anticancer drugs. Its degradation and drug release behavior was herein studied in phosphate buffer solution at pH 7.4 and 37o C. Anticancer drugs deguelin and cisplatin were loaded into wafers made of the new polyanhydride, poly(sebacic acid–co-hydroxylauric acid maleate) anhydride for controlled drug release studies and comparison. The polyanhydride showed that it is degradable, biocompatible and non cytotoxic. Using poly(sebacic acid–co-hydroxylauric acid maleate) anhydride wafers containing 5% deguelin, the device can provide a controlled release of deguelin in 20 days delivering 84.6% cumulative release of the drug while following a zero order model of release kinetics. Similarly the device can also provide a controlled release of cisplatin in 7 days delivering 71.22% cumulative release of the drug following also a zero order model of release kinetics. The mechanism of both drug releases was determined to be by diffusion. This drug-loaded polyanhydride system could find application in localized treatment such as in decreasing tumor size, in preventing tumor recurrence or in post-operative cancerous tumor extraction.
INTRODUCTION
Currently drugs combined with polymeric carriers are being developed for controlled release to replace drugs which have short uncontrolled release profile. They are being developed to control drug release with fewer doses for localized treatment that avoids toxicity associated with systemic drug delivery. Among these polymeric drug delivery systems are the polyanhydrides which have been studied in detail over the past few decades. Polyanhydrides as drug carriers have many desirable characteristics that made them a good choice for drug delivery. For example they surface erode in media, rather than erode in bulk, ultimately controlling drug release rates (Johnson 2008).
Although a variety of polymer structures have already been reported since the discovery of polyanhydrides, the most important type used are the aliphatic polyanhydrides (Jain et al. 2005) .These polyanhydrides are biodegradable, due mainly to their anhydride linkages, and highly biocompatible, unlike the aromatic types, that made this group of polymers an excellent material . . . . read more
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