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Lack of Association Between Lipid and Lipoprotein
Profile with Menopause Status in Women
with Cardiac Syndrome X

Yousef Rasmi1,2, Esmail Khademy3, Maryam Majidinia4,
MirHossein Seyyed-Mohammadzad5, Reza Hajhosseini3, Fariba Khosravifar3,
Ehsan Saboory6, Sam Seidi-Shirvani3, and Mohammad Rahmati-Yamchi4

1Cellular and Molecular Research Center,
Urmia University of Medical Sciences, Urmia, Iran
2Department of Biochemistry, Faculty of Medicine,
Urmia University of Medical Sciences, Urmia, Iran
3Department of Biology, Tehran Payam-e- Noor University, Tehran, Iran
4Department of Biochemistry, Faculty of Medicine,
Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Cardiology, Faculty of Medicine,
Urmia University of Medical Sciences, Urmia, Iran
6Neurophysiology Research Center, Urmia University of Medical Sciences,
Urmia, Iran

corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Cardiac syndrome X (CSX, angina pectoris, positive findings on exercise electrocardiography and normal results on coronary angiography) frequently occurs in menopausal women. On the other hand, studies indicated that menopause is associated with alteration in lipid profile and increased risk of cardiovascular diseases. Therefore, we aimed to determine the possible influence of menopause on lipid and lipoprotein profile in women with CSX. Fifty women with CSX (mean age: 52.4±7.65 years) and 50 healthy women as control (50.0±5.62 years) were studied. We divided CSX and control groups as pre- and post-menopause subgroups. The plasma lipid and lipoprotein profile of subjects was estimated colorimetrically. In CSX group, the total cholesterol (TC), triglyceride (TG), lipoprotein A(LP[a]), low density lipoprotein (LDL), high density lipoprotein (HDL), apoprotein A1(APOA1), apoprotein B (APOB) were significantly higher than those of the control group. (TC: 158.2±5.7 vs. 114.5±5.1mg/dl; P=0.001, (TG: 152.1±11.4 vs. 105.9±8.9mg/dl; P=0.002, LP[a]: 44.2±7.9 vs. 22.2±4.3mg/dl; P=0.017, LDL: 88.9±3.7 vs. 66.1±23.4mg/dl; P=0.001, HDL: 36±1.4 vs. 29.3±0.8mg/dl; P=0.001, APOA1: 120.9±1.6 vs. 107.7±1.5mg/dl; P=0.001, and APOB: 95.2±3.4 vs. 74.4±2.6mg/dl; P=0.001). The differences of lipid and lipoprotein profile between pre- and post-menopause CSX was not significant. Plasma lipid disorders play important roles in the development of CSX. Changes that occur in the lipid profile after menopause are not associated with increased CSX.

 

INTRODUCTION

The occurrence of typical chest pain and ST-segment changes suggestive of myocardial ischemia in patients who otherwise have completely normal coronary arteriograms is called as ‘‘syndrome X’’, as termed by Harvey Kemp in 1973 (Kemp, 1973), or ‘‘cardiac syndrome X’’ [CSX] or microvascular angina . . . . . read more

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