Analgesic and Hypoglycemic Activities of Bixa orellana, Kyllinga monocephala, and Luffa acutangula
Jusal P. Quanico1, Evangeline C. Amor1,2*, and Grace C. Perez3
1Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City, Philippines
2Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines
3School of Statistics, University of the Philippines, Diliman, Quezon City, Philippines
*corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The analgesic and hypoglycemic activities of Bixa orellana, Kyllinga monocephala, and Luffa acutangula were evaluated. Methanol extracts of B. orellana and L. acutangula showed significant hypoglycemic activities when administered 15 min after glucose load using a modified oral glucose tolerance test with Swiss Webster mice as test animals. An infusion of B. orellana was found to lower blood glucose level when administered 45 min before glucose load, while that of K. monocephala was found to lower blood glucose level when administered 15 min after glucose load. The methanol extract of K. monocephala was found to significantly reduce the number of writhes in mice administered intraperitoneally with acetic acid to induce abdominal constriction, while those of B. orellana and L. acutangula did not.
INTRODUCTION
In spite of recent advances in health care in the Philippines, diabetes mellitus continues to be 1 of the top 10 chronic diseases that afflicts millions of Filipinos, 95% of which suffer from non-insulin-dependent diabetes mellitus (NIDDM: Type II) alone (Villaseñor & Lamadrid 2006). In contrast with insulin-dependent diabetes mellitus (IDDM: Type I), where the usual remedy is subcutaneous injection of insulin, NIDDM can be regulated through exercise, diet, and oral hypoglycemic drugs (Lamba et al. 2000). Hence only the NIDDM model was used in this work.
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