PJS Vol 135 No. 2, December 2006
Page 83-92
ISSN 0031-7683
A Modified Procedure for the Preparation of Mitoxantrone
The anticancer drug mitoxantrone is commercially prepared in four synthetic steps starting from readily available chrysazin. A new and modified procedure for a similar process of mitoxantrone preparation has been successfully applied in small-scale preparation of mitoxantrone in our laboratories. This new process was designed to be practicable under Philippine setting. Success of the synthesis was established by full physico-chemical and spectral characterization of all intermediates and of the final mitoxantrone product. The cytotoxic activity of the synthesized mitoxantrone was tested against MCF-7 breast cancer cell lines and was found to be similar to commercially available mitoxantrone.
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