A Survey of Lectin-like Activity in Philippine Marine Invertebrates
Elmer-Rico E. Mojica1,2,*, Custer C. Deocaris3,4,5 and Florinia E. Merca1
1Institute of Chemistry, University of the Philippines Los Baños,
College, Laguna, Philippines
2Department of Chemistry, State University of New York at Buffalo,
Buffalo, NY, USA
3Department of Chemistry and Biotechnology, School of Engineering
University of Tokyo, 7-3-1, Hongo, Tokyo, Japan
4National Institute of Advanced Industrial Science and Technology (AIST)
1-1-1 Higashi, Tsukuba Science City, Ibaraki, 305-8562, Japan
5Philippine Nuclear Research Institute, Commonwealth Avenue
Diliman Quezon City, Philippines
corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Owing to their sugar-recognition specificities, lectins have now become useful tools in targeting carbohydrates on cell surfaces. Using an in vitro hemagglutination assay, we screened several marine invertebrates found in the Philippines to catalog new biosources for these lectins. We found fifty-nine (59) species showing lectin-like activity out of the 90 analyzed and described individual hemagglutination characteristics. Underscoring the diversity and abundance of marine lectin sources, this work hopes to provide valuable information relevant for “farming” novel lectins for biotechnology especially in developing nations with rich marine resources.
INTRODUCTION
Lectins are sugar-binding proteins of non-immune origin, which agglutinate cells or precipitate glycoconjugates. These molecules are capable of specific recognition and reversible binding to carbohydrates without altering their . . . .
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