Alkaloids from Pandanus amaryllifolius Collected from Marikina, Philippines


Daisy C. Lopez1,2*, Maribel G. Nonato2*, Hiromitsu Takayama3,
Tomotake Ichikawa3, Mariko Kitajima3, and Norio Aimi3

1Philippine Textile Research Institute, Department of Science and Technology
Bicutan, Taguig, Metro Manila, Philippines
2Graduate School and Research Center for the Natural Sciences
University of Santo Tomas, España, Manila 1008, Philippines
3Graduate School of Pharmaceutical Sciences, Chiba University
1-33 Yayoi, Inage-ku, Chiba 263-8522, Japan

corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.



The dichloromethane extract from a neutral partition of the alcoholic extract of air-dried mature leaves of Pandanus amaryllifolius from Marikina, Philippines yielded Pandamarilactone-1 (2), Pandamarilactam-3x, -3y (5-6), Pandamarilactonine-A, -B, -C (7-9), and 6Z-Pandanamine (13). The isolation of these alkaloids by this study corroborated the results from other countries despite the differences in the sites and years of leaves collection and in the extraction and partitioning conditions, which strongly suggests that these alkaloids are natural products of P. amaryllifolius and are not experimental artifacts.



Pandanus amaryllifolius Roxb. (syn. P. odorus Ridl.) is one of the more than 600 Pandanus species that are widely distributed in the tropical and subtropical areas (Stone 1978, 1983). Many ethnomedical reports and pharmacological . . . .





AZARES GF, GARSON MJ and NONATO MG. 1999. Chemical studies and structure elucidation of the alkaloids from the leaves of Pandanus dubius Spreng. (Pandanacea). In: Recent developments in the discovery of biologically active natural products. Quezon City: Ateneo De Manila University. p. 6-7.

BYRNE LT, GUEVARA BQ, PATALINGHUG WC, RECIO BB, UALAT CR, WHITE AH. 1992. The X-ray crystal structure of (+)Pandamarine, the major alkaloid of Pandanus amaryllifolius. Aust J Chem 45: 1903-08.

JONG TT, CHAU SW. 1998. Antioxidative activities of constituents isolated from Pandanus odoratissimus. Phytochemistry 49: 2145-48.

NONATO MG, GARSON MJ, TRUSCOTT RJW, CARVER JA. 1993. Structural characterization of piperidine alkaloids from Pandanus amaryllifolius by inverse-detected 2D NMR techniques. Phytochemistry 34: 1159-63.

NONATO MG, MADULID RS. 1997. Alkaloid bearing Pandanus species in Luzon, Philippines. Acta Manilana 45: 21-27.

PEUNGVICHA P, THIWARAPAN SS, WATANABE H. 1998. Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root. Jap J Pharm 78: 395-398.

SALIM AA, GARSON MJ, CRAIK DJ. 2004. New alkaloids from Pandanus amaryllifolius. J Nat Prod 67: 54-57.

SANTOS AC, SANTOS GA, OBLIGACION MBS, OLAY LP, FOJAS FR. 1981. Philippine plants and their contained natural products: Biological and pharmacological literature survey. Taguig, Metro Manila: National Research Council of the Philippines.

SJAIFULLAH A, GARSON MJ. 1996. Structural characterization of two novel pyrrolidinones from Pandanus amaryllifolius Roxb. ACGC Chemical Research Communications 5: 24-27.

STONE BC. 1978. Studies in Malesian Pandanaceae XVII on the taxonomy of ‘pandan wangi’ a Pandanus cultivar with scented leaves. Econ Bot 32: 285-93.

STONE BC. 1983. A guide to collecting Pandanaceae (Pandanus, Freycinetia, and Sararanga). Annual Missouri Botanical Garden 70: 137-45.

TAKAYAMA H, ICHIKAWA T, KUWAJIMA T, KITAJIMA M, SEKI H, AIMI N, NONATO MG. 2000. Structure characterization, biomimetic synthesis, and optical purity of two new pyrrolidine alkaloids, Pandamarilactonine-A and –B, isolated from Pandanus amaryllifolius Roxb. J Am Chem Soc 122: 8635-39.

TAKAYAMA H, ICHIKAWA T, KITAJIMA M, AIMI N, LOPEZ D, NONATO MG. 2001a. A new alkaloid, Pandanamine: finding of an anticipated biogenetic intermediate in Pandanus amaryllifolius Roxb. Tetrahedron Letters 42: 2995-96.

TAKAYAMA H, ICHIKAWA T, KITAJIMA M, NONATO MG, AIMI N. 2001b. Isolation and characterization of two new alkaloids, Norpandamarilactonine-A and –B, from Pandanus amaryllifolius by spectroscopic and synthetic methods. J Nat Prod 64: 1224-25.

TAKAYAMA H, ICHIKAWA T, KITAJIMA M, NONATO MG, AIMI N. 2002. Isolation and structure elucidation of two new alkaloids, Pandamarilactonine-C and -D, from Pandanus amaryllifolius and revision of relative stereochemistry of Pandamarilactonine-A and -B by total synthesis. Chem Pharm Bull 50: 1303-04.

YSRAEL MC, SANTIAGO M, NONATO MG. 1995. Diuretic studies of five Pandanus species. Acta Manilana 43: 25-30.