Antimicrobial Compounds from Artocarpus heterophyllus
Consolacion Y. Ragasa, Karen Jorvina and John A. Rideout
Department of Polymer Science and Engineering Research Institute of Industrial Technology, Gyeongsang National University, Chinju Gyeongnam, Korea
corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The freeze-dried unripe fruit of Artocarpus heterophyllus Lam., common name: langka, afforded cycloartenone 1, cycloartenol 2, and a diastereomeric mixture of 2,3-butanediols 3a and 3b in a 3:1 ratio. Antimicrobial tests on 1-3 indicated that 1 has low activity against E. coli, P. aeruginosa, and T. mentagrophytes, moderate activity against C. albicans and A. niger and inactive against S. aureus and B. subtilis. 2 has no antibacterial activity and only low antifungal activity. The diastereomeric mixture of 3 exhibited high activity against P. aeruginosa, moderate activity against C. albicans, and low activity against S. aureus, T. mentagrophytes, and A. niger. 3 has the same activity as the standard antibiotic against P. aeruginosa.
INTRODUCTION
Artocarpus heterophyllus Lam., commonly known as langka, is cultivated throughout the Philippines, for its fruit which is eaten fresh or made into preserves and other sweets. The unripe fruit is used as astingent, while the ripe fruit is used as demulcent, nutritive and laxative (Quisumbing 1978). A number of studies were conducted on A. heterophyllus which reported the isolation of cycloartenone, cycloartenol, and other tetracyclic tripertenoids (Baric et al. 1994), flavonoids (Lu & Lin 1994; Lu et al. 1995; Radhakrishnan et al. 1965; Chung et al. 1995), and Deils-Alder-type adducts (Shinomiya et al. 1995; Aida et al. 1990). . . . . .
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