Philippine Journal of Science
150 (5): 1245-1254, October 2021
ISSN 0031 – 7683
Date Received: 19 Apr 2021

 

Biological Activity and Chemical Profiling of Terrestrial
and Freshwater Cyanobacteria from the Philippines

Jeremiah D. Batucan¹, Shalice R. Susana¹, Michelle Marie T. Ochoa²,
and Lilibeth A. Salvador-Reyes¹*

¹The Marine Science Institute; ²Institute of Chemistry
National Science Complex, University of the Philippines Diliman
Diliman, Quezon City 1101 Philippines

*Corresponding author: lsreyes@msi.up.edu.ph

 

ABSTRACT

 

A total of 23 cyanobacteria cultures were extracted and sequentially solvent partitioned with hexane, n-butanol (n-BuOH), and water. The n-BuOH extracts were tested for antiproliferative effects against HCT116 human colorectal adenocarcinoma cells, anti-inflammatory activity on lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells, and antimalarial activity vs. Plasmodium falciparum W2. Eleven (11) and two extracts showed antiproliferative and anti-inflammatory activity, respectively. None of the extracts were antimalarial. Bioactivityguided purification of the n-BuOH extracts from Hapalosiphon welwitschii Cy 51 and Oscillatoria obscura Cy 13 yielded seven antiproliferative indole alkaloids. This work highlights the potential of terrestrial and freshwater cyanobacteria from the Philippines as a source of bioactive and structurally diverse natural products.