Philippine Journal of Science
149 (1): 35-41, March 2020
ISSN 0031 – 7683
Date Received: 30 Jul 2019

 

BAG6 Variant rs805303 is Nominally Associated
with ACEi-induced Cough among Filipinos

 

Paul Ferdinand M. Reganit1, Jose B. Nevado, Jr.2, Eva Maria C. Cutiongco–de la Paz2,3, Jezreel L. Taquiso1, Aimee Yvonne Criselle L. Aman2,3, Elmer Jasper B. Llanes1, Jose Donato A. Magno1, Deborah Ignacia D. Ona1, Felix Eduardo R. Punzalan1, Lourdes Ella G. Santos1, Richard Henry P. Tiongco II1, Jaime M. Aherrera1, Lauro L. Abrahan IV1, Charlene F. Agustin1, Adrian John P. Bejarin2,3, and Rody G. Sy1*

 

1Department of Medicine, Philippine General Hospital

2Institute of Human Genetics, National Institutes of Health University of the Philippines Manila, Ermita, Manila, Philippines

3Philippine Genome Center, University of the Philippines Diliman
Diliman, Quezon City, Philippines

 

*Senior corresponding author: rodysymd@gmail.com

 

[Download]
Reganit PF et al. 2020. BAG6 Variant rs805303 is Nominally Associated
with ACEi-induced Cough among Filipinos. Philipp J Sci 149(1): 35–41.
https://doi.org/10.56899/149.01.04

 

ABSTRACT

Cough is a common side effect of angiotensin converting enzyme inhibitor (ACEi) therapy. The incidence of ACEi-induced cough has been shown to correlate with genetic variation among different populations. This study aimed to determine the association of candidate genetic polymorphisms with ACEi-induced cough among Filipinos. Two hundred twenty (220) participants on ACEi therapy pressure-lowering in an unmatched case-control study (82 cases with ACEiinduced cough and 138 controls). Genomic DNA samples were extracted and genotyped for selected genetic variants. The association of genetic variants and clinical factors with ACEi-induced cough was determined using regression analyses. Univariate logistic regression showed that the BAG6 variant rs805303 is nominally associated with ACEi-induced cough among Filipinos, at a percomparison error rate (PCER) of 0.05 (OR 2.10, p = 0.016). The association of the variant with ACEi cough was statistically significant after multiple regression analysis (adjusted OR 2.09, p = 0.022) while adjusting for confounding clinical factors (sex, alcohol intake, and diastolic blood pressure). Further studies are needed to validate these findings.