Philippine Journal of Science
151 (2): 655-663, April 2022
ISSN 0031 – 7683
Date Received: 05 Oct 2021
Association of Omentin rs2274907 Gene
Polymorphism and Its Protein on the Risk
of Obesity and Metabolic Disorder in Thai Children
Banchamaphon Pheungruang1, Kanjana Suriyaprom2, Anchalee Tungtrongchitr3,
Piyaporn Karuwanarint3, Chutima Sirikulchayanonta4, Pattaneeya Prangthip1,
Karunee Kwanbunjan1, and Rungsunn Tungtrongchitr1*
1Department of Tropical Nutrition and Food Science
Faculty of Tropical Medicine Mahidol University, Bangkok 10400 Thailand
2Faculty of Medical Technology, Rangsit University, Pathumthani 12000 Thailand
3Department of Parasitology, Faculty of Medicine Siriraj Hospital
Mahidol University, Bangkok 10700 Thailand
4College of Medicine, Rangsit University, Bangkok 10400 Thailand
*Corresponding author:
rungsunn.tun@mahidol.ac.th; rungsunn@gmail.com
[Download]
Pheungruang B et al. 2022. Association of Omentin rs2274907 Gene Polymorphism and Its Protein on the Risk
of Obesity and Metabolic Disorder in Thai Children. Philipp J Sci 151(2): 655–663. https://doi.org/10.56899/151.02.08
ABSTRACT
Omentin is an adipocytokine that expresses in white adipose tissues. It is a marker for preventing the development of pro-inflammatory states related to diseases like obesity. This study aimed to examine the concentrations of omentin and anthropometric-biochemical parameters in obese children and healthy controls. Also, to search for the associations of omentin rs2274907 gene polymorphism with omentin levels and obesity among Thai children. A total of 293 children, 178 obese cases and 115 healthy controls, were recruited for this study. The omentin level was measured using the enzymelinked immunosorbent assay (ELISA), and genotyping was performed using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Serum omentin levels were significantly lower in the obese group than in the control group (13.9 and 25.0 ng/mL, respectively, p < 0.001). The omentin levels had significant negative correlation with body weight, body mass index (BMI) percentile, waist circumference, triglycerides (r = –0.276, –0.275, –0.259, –0.242, p < 0.001), and had positive correlation with high-density lipoprotein cholesterol (HDL-C) levels (r = 0.210, p < 0.001). There was a significant association between obesity and serum omentin levels (p < 0.05). However, the omentin rs2274907 gene polymorphism showed no significant relationship with the omentin levels and obesity among Thai children. These findings in Thai children suggest that omentin level, but not omentin rs2274907 gene polymorphism, may influence susceptibility to obesity.